Chapter Iii Synthesis, X-ray Structural and Vibrational Analysis Using Dft Study of 4-methyl-n- (naphthalene-1-yl)benzene Sulfonamide

Sulfonamides, an important class of pharmaceutical compounds exhibit a wide spectrum of biological activities [1-3]. Over 30 drugs containing this functionality are inclinical use, including, antibacterials, diuretics, anticonvulsants, hypoglycemics and HIV protease inhibitors[4 ]. More recently, sulfonamides have been found to be potent cysteine protease inhibitors, which could possibly extend their therapeutic applications to include conditions such as Alzheimer’s disease, arthritis and cancer [5-6]. The vast majority of sulfonamides are prepared from the reaction of a sulfonyl chloride with ammonia or primary or secondary amines or via related transformations [7,8].